generalized periodontitis, structural and functional disorders, gingival microcirculation, pharmacotherapy, drugs


According to the WHO estimates, severe periodontal disease affects about 19% of the world's adult population, accounting for more than one billion cases worldwide. The main risk factors for periodontal disease are poor oral hygiene and tobacco use. Oral diseases cover a range of diseases and conditions that include dental caries, periodontitis (gum disease), tooth loss, oral cancer, orodental injuries, nomas and birth defects such as cleft lip and palate. The relevance of conducting a study of structural and functional disorders of gingival microcirculation in generalized periodontitis is substantiated. Synchronous changes in indicators of the functional state of the periodontal vessels and the microcirculatory bed are observed in the periodontium. The study of structural and functional parallels of the hemomicrocirculatory channel of the periodontium shows that one of the links of the pathogenetic theory of generalized periodontitis is vascular. This study can be used for effective, targeted, comprehensive treatment of generalized periodontitis during pharmacotherapy using drugs of various clinical and pharmacological, nomenclature and legal, classification and legal groups; study of pharmacoeconomic indicators regarding the availability of medicines to this contingent of patients. It has been proven that ultrastructural changes in the plasmolemma of endotheliocytes, both on the side of the vessel lumen and on the side of the basal membrane, indicate a violation of vascular permeability.


World Health Assembly Resolution paves the way for better oral health care. WHO. 27.05.2021. URL:

Oral health. WHO. 14.03.2023. URL:

The State of Oral Health in Europe. Oral health in Europe. 2012. URL:

Economist report shows prevalence of periodontitis unchanged over 20 years. EFP. 28.06.2021. URL:

Eke P.I., Dye B., Wei L. et al. Prevalence of Periodontitis in Adults in the United States: 2009 and 2010. J. Dent. Res. 30.08.2012. Р. 1-7. URL:

Periodontal Disease. CDC. 27.04.2023. URL:

Lee S.R., Han M.A., Park J. et al. Oral health status and behavior in elderly Koreans with periodontal disease. J. Public. Health. Dent. 2022. Vol. 82. No.4. P. 378-384. URL:

Мазур І.П., Вахненко О.М. Моніторинг основних показників стоматологічної допомоги в Україні за 2019 рік. Oral and general health. 2020. Т. 1. №1. URL:

Надання стоматологічної медичної допомоги Національною службою здоров’я України у цьому році виокремлено в окремий пакет, який оплачується за кошти державного бюджету. Львівська обласна державна адміністрація. 13.05.2021 URL:

Фесенко В.І., Круть Ю.О. Взаємозв’язок хвороб пародонту з ендокринними захворюваннями (за даними літератури). Proceedings of academic science: «Materials of the XVII International scientific and practical conference». August 30 - September 7, 2021. Sheffield Science and Education LTD. 2021. Vol. 2. Р. 31-43. URL:

Ковальов Є.В., Назаренко З.Ю. Корекція мікроциркуляторних порушень у яснах хворих на хронічний генералізований пародонтит на тлі цукрового діабету. Український стоматологічний альманах. 2008. №5. С.56.

Борисенко А.В., Ватанха Т.В. Стан тканин пародонту в жінок, які приймають оральні контрацептиви. Сучасна стоматологія. 2018. № 2. С. 34-35.

Hayduchok I.G., Shapovalova V.O., Ishcheikin K.E., Chopyak V.V., Shapovalov V. V. (Jr.), Shapovalov V.V. Pharmacoeconomic approaches for pharmacotherapy of rheumatoid arthritis. Likars’ka Sprava. 2021. No 1-2. P. 70-79. URL:

Ryabukha O. Mathematical methods in biomedical studies: the need for new approaches to study of follicular thyrocytes. SSP Modern Pharmacy and Medicine. 2022. Vol. 2. No 2. Р. 1-17. URL:

Ivanishyn-Hayduchok L., Shapovalova V., Shapovalov V. ICD-11: Organizational and legal, medical and pharmaceutical, social and economic issues of implementation of the program of state guarantees of medical care in 2022 in Ukraine, based on the fundamental principles of the European Union. SSP Modern Pharmacy and Medicine. 2022. Vol. 2. No 2. 1-14. URL:

Shapovalov Valentyn, Osyntseva A., Shapovalov V. Organization of pharmaceutical business, drug technology, forensic and clinical pharmacy: multidisciplinary innovative nanotechnologies in the development and implementation of new medical products to medical and pharmaceutical practice. SSP Modern Pharmacy and Medicine. 2022. Vol. 2. No 3. P. 1-18. URL:

Shapovalova V. Interdisciplinary pharmacoeconomic research concerning the pharmacotherapy of Аlcoholic Hepatitis in conditions of COVID-19 pandemic. SSP Modern Pharmacy and Medicine. 2023. Vol.3. No.2. P.1-10. URL:

Shapovalov V. Multidisciplinary Study of medical errors in the system of legal relations between "Doctor-Patient-Pharmacist-Advocate" during the circulation of drugs. SSP Modern Pharmacy and Medicine. 2023. Vol.3. No.2. P.1-11. URL:

Hayduchok І., Shapovalov V. Covid-19: multidisciplinary researches of forensic and pharmaceutical risks and causal relationships of unqualified medical care for patients during pandemic. 2022. SSP Modern Law and Practice. Vol.2. No.1. P.1-25. URL:

Shapovalova V. Forensic and pharmaceutical risks in the organization of pharmacotherapy of covid, post-covid and long-covid disorders. COVID-19 and vaccination practice standards. SSP Modern Pharmacy and Medicine. 2022. Vol. 2. No. 4. P. 1–24. URL:

Shapovalova V., Shapovalov V., Osyntseva A. et al. Organization of the pharmaceutical business, industrial pharmacy and forensic pharmacy concerning the competences of quality management during the circulation of medical products: GxP standards. Actual problems of medicine and pharmacy. 2022. Vol.3. Nо. 2. P.1–20. URL:

Shapovalova V. The ICD-11 for the twenty-first century: the first view from the organizational, legal, clinical and pharmacological aspects. SSP Modern Pharmacy and Medicine. 2022. Vol.2. Nо.1. P.1-13. URL:

Мазур І.П., Супрунович І.М., Стадник М.Б. Моніторинг призначень фармацевтичних препаратів лікарями-стоматологами протягом 2019-2020 років. Oral and general health. 2020. Т. 1. №1. URL:

Класифікація захворювань тканин пародонту та периімплантних тканин (EFP & AAP World Workshop, 2017). UAP. 01.05.2020. URL:

Борисенко А.В. Нова класифікація захворювань пародонта і періімплантних станів (2017). Сучасна стоматологія. 2019. № 3. С. 24-27. URL:

Oral health. WHO. 27.04.2023. URL:

Shevchuk M.М. The percentage and structure of perodont tissue diseases in patients of Lviv regional stationary clinical hospital depending on age. Український стоматологічний альманах. 2018. № 4. C. 16-21. URL: file:///C:/Users/valer/Downloads/345-Article%20Text-681-1-10-20190104%20(1).pdf

Riznyk С., Riznyk Ю., Pyndus Т., Pyndus В. Endothelial dysfunction of periodontal vasculature of generalized periodontitis. Actual Problems of Medicine and Pharmacy. 2022. Vol. 3. No 1. P. 1-9. URL:

Заболотний Т.Д., Борисенко А.В. Генералізований пародонтит. Львів: ГалДент. 2013. 240 с.

Заболотний Т.Д., Путін Т.І. Загальні захворювання пародонта. Львів: ГалДент. 2013. 206 с.

Михалева Л.М., Баркина Т.Г., Шаповалов В.Д. Ультраструктурная характеристика кровеносных сосудов микроциркуляторного русла десен при хроническом пародонтите. Архив патологии. 2012. Т. 64. - №2. C. 45-48.

Ярова С.Р., Мозгова Н.В. Роль судинних змін в перебігу генералізованого пародонтиту. Український стоматологічний альманах. 2004. №3-4. C. 23-26.



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